URB1

Across TCGA patient cohorts, URB1 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible URB1-associated genes across cancer lineages are TFRC, Caspase-7-cleavedD198, and Transglutaminase. Each is linked with URB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both URB1-to-partner and partner-to-URB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by URB1-low versus URB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (URB1→partner) and Y-score (partner→URB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.379	+1.584	.005	.008	3	3
UCEC	Caspase-7-cleavedD198 →	+0.618	+1.584	<.001	.003	3	3
BRCA	Transglutaminase →	+0.233	+3.000	.012	.037	3	2
UCEC	eEF2 →	+0.246	+1.514	.007	.012	3	2
UCEC	Ku80 →	+0.121	+0.843	.047	.035	3	2
UCEC	mTOR_pS2448 →	-0.080	-0.830	.036	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

TFRC by URB1 expression — UCEC

Explore this box plot interactively →