URB1

Across TCGA cell cohorts, URB1 mutation is significantly associated with the RNA expression of many other genes, with 348 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible URB1-associated genes across cancer lineages are FAM171A1, PPIAL4F, and ARMH2. Each is linked with URB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both URB1-to-partner and partner-to-URB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM171A1 grouped by URB1-low versus URB1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (URB1→partner) and Y-score (partner→URB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FAM171A1 →	+1.531	+3.064	.002	.009	3	3
LUNG_NSCLC_LUSC	PPIAL4F →	+0.114	+4.108	<.001	.005	3	2
OESOPHAGUS	ARMH2 →	+0.030	+4.906	<.001	.006	3	2
PANCREAS	MORN5 →	+0.261	+3.491	.007	.004	3	2
URINARY_TRACT	OR51I1 →	+0.136	+4.217	<.001	.005	3	2
SKIN	GOLPH3L →	+0.924	+2.451	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 348 associations by consensus.

FAM171A1 by URB1 expression — SKIN

Explore this box plot interactively →