URB1

Across TCGA cell cohorts, URB1 mutation is significantly associated with the mutation status of many other genes, with 5,451 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible URB1-associated genes across cancer lineages are ALS2CL, NBAS, and PCDH10. Each is linked with URB1 in more than 4 cancer types. Because this analysis shows association rather than direction, both URB1-to-partner and partner-to-URB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ALS2CL grouped by URB1-low versus URB1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (URB1→partner) and Y-score (partner→URB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ALS2CL →	+3.604	+2.532	.001	.001	1	5
LUNG_SCLC	NBAS →	+3.437	+3.977	<.001	<.001	1	5
BLOOD_Leukemia	PCDH10 →	+3.783	+2.430	<.001	<.001	1	5
LARGE_INTESTINE	PKD1L1 →	+1.452	+1.874	.002	.002	1	5
LARGE_INTESTINE	EVPL →	+1.693	+2.058	.001	.001	1	5
BLOOD_Leukemia	PEG3 →	+2.046	+1.921	.001	.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,451 associations by consensus.

ALS2CL by URB1 expression — SKIN

Explore this box plot interactively →