URB1-AS1

Across TCGA pan-cancer cohorts, URB1-AS1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated URB1-AS1 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher URB1-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated URB1-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and OV show a favorable association.

LUSC, CHOL, and MESO are the cancer types where URB1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.702	0.555	.007	54	view →
CHOL	DFS	Median	II,III,IV	0.139	0.617	.002	35	view →
MESO	OS	Tertile	All	0.364	0.614	.008	34	view →
KIRC	DFS	Median	II,III,IV	0.733	0.832	.012	28	view →
OV	OS	Tertile	IV	0.760	0.369	.001	28	view →
ESCA	DFS	Quartile	II,III,IV	1.000	0.120	.006	27	view →
ACC	DFS	Quartile	All	0.130	0.650	.018	15	view →
UCEC	DFS	Median	IV	0.817	0.541	.009	14	view →
LIHC	DFS	Median	All	0.374	0.491	.004	14	view →
LGG	OS	Quartile	All	0.745	0.868	.008	11	view →
SKCM	DFS	Median	All	0.669	0.551	.003	8	view →
READ	DFS	Median	III,IV	0.761	0.327	.027	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

URB1-AS1–LUSC (OS)

Open the LUSC breakdown →