Across TCGA pan-cancer cohorts, UQCRFS1P3 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of UQCRFS1P3’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where UQCRFS1P3 RNA is repressed in tumor relative to normal tissue. In most cancer types UQCRFS1P3 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.
THCA and KIRP are the cancer types where UQCRFS1P3 tumor–normal differential expression is most reproducible.