UQCRC1

Across TCGA patient cohorts, UQCRC1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UQCRC1-associated genes across cancer lineages are MEK1, MSH6, and PRDX1. Each is linked with UQCRC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UQCRC1-to-partner and partner-to-UQCRC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by UQCRC1-low versus UQCRC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UQCRC1→partner) and Y-score (partner→UQCRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.402	+2.321	.028	.035	3	1
UCEC	MSH6 →	-0.492	-2.990	.002	.036	3	1
UCEC	PRDX1 →	+0.228	+2.999	.028	.035	3	1
UCEC	ERK2 →	+0.224	+3.459	.020	.005	2	1
UCEC	MSH2 →	-0.336	-2.990	.003	.036	2	1
UCEC	ATM →	-0.667	-3.459	.003	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MEK1 by UQCRC1 expression — UCEC

Explore this box plot interactively →