UQCRC1

Across TCGA cell cohorts, UQCRC1 mutation is significantly associated with the mutation status of many other genes, with 2,042 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UQCRC1-associated genes across cancer lineages are ITGAL, PIGQ, and MMP25. Each is linked with UQCRC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UQCRC1-to-partner and partner-to-UQCRC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGAL grouped by UQCRC1-low versus UQCRC1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UQCRC1→partner) and Y-score (partner→UQCRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ITGAL →	+4.047	+5.099	<.001	<.001	1	2
BLOOD_Leukemia	PIGQ →	+3.038	+3.347	.002	.002	1	2
BLOOD_Leukemia	MMP25 →	+3.360	+3.946	<.001	<.001	1	2
OVARY	APC2 →	+3.632	+3.930	.003	.003	1	2
OVARY	MSH6 →	+3.217	+3.684	.006	.006	1	2
OVARY	DDX59 →	+3.217	+3.684	.006	.006	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,042 associations by consensus.

ITGAL by UQCRC1 expression — OVARY

Explore this box plot interactively →