Across TCGA pan-cancer cohorts, UQCC3 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of UQCC3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where UQCC3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types UQCC3 is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and PDAC are the cancer types where UQCC3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UQCC3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	−0.557	<.001	11	view →
COAD	All	All	−0.355	<.001	6	view →
PDAC	All	All	−0.320	.021	2	view →
LUAD	All	All	−0.146	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: UQCC3 RNA expression & survival · all UQCC3 data types