UQCC2

Across TCGA pan-cancer cohorts, UQCC2 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of UQCC2’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where UQCC2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UQCC2 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

LIHC, LUAD, and COAD are the cancer types where UQCC2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UQCC2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.585	<.001	9	view →
LUAD	Male	II,III,IV	+1.204	<.001	9	view →
COAD	Female	II,III,IV	+1.032	<.001	9	view →
BLCA	All	All	+0.645	<.001	8	view →
HNSC	Male	III,IV	+0.641	<.001	8	view →
KICH	Female	II,III,IV	−1.540	<.001	7	view →
LUSC	Female	II,III,IV	+1.331	<.001	7	view →
BRCA	All	III,IV	+0.880	<.001	6	view →
UCEC	All	All	+0.717	<.001	6	view →
STAD	All	II,III,IV	+0.679	<.001	6	view →
KIRC	Male	All	−0.544	<.001	6	view →
KIRP	Female	II,III,IV	+0.471	.005	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

UQCC2–LIHC

Open the LIHC breakdown →