UQCC1

Across TCGA patient cohorts, UQCC1 mutation is significantly associated with the RNA expression of many other genes, with 335 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UQCC1-associated genes across cancer lineages are ATP5MC1P5, NFU1P1, and OR2K2. Each is linked with UQCC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UQCC1-to-partner and partner-to-UQCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP5MC1P5 grouped by UQCC1-low versus UQCC1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UQCC1→partner) and Y-score (partner→UQCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	ATP5MC1P5 →	+0.133	+3.872	.005	.008	3	2
BLCA	NFU1P1 →	+0.052	+3.840	.004	.006	3	2
SKCM	OR2K2 →	+0.055	+2.602	.004	.001	3	2
SKCM	RNA5SP192 →	+0.075	+4.025	<.001	.007	3	2
UCEC	RNA5SP499 →	+0.152	+4.601	<.001	.003	3	2
UCEC	IGHD3-16 →	+1.376	+2.318	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 335 associations by consensus.

ATP5MC1P5 by UQCC1 expression — BLCA

Explore this box plot interactively →