UPRT

Across TCGA pan-cancer cohorts, UPRT Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UPRT data layer compared with 21 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher UPRT Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated UPRT expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD, HNSC, and LUAD are the cancer types where UPRT Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	III,IV	0.239	0.791	.014	23	view →
HNSC	DFS	Median	II,III,IV	0.218	0.687	.001	21	view →
LUAD	OS	Median	All	0.295	0.700	.006	9	view →
UCEC	DFS	Median	All	0.896	0.611	.018	8	view →
LUSC	DFS	Median	All	0.136	0.791	.005	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UPRT–COAD (OS)

Open the COAD breakdown →