UPRT

Across TCGA pan-cancer cohorts, UPRT mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated UPRT data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher UPRT mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated UPRT expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where UPRT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	II,III,IV	0.853	0.442	.005	24	view →
PDAC	DFS	Median	All	0.841	0.676	.023	8	view →
HNSC	DFS	Median	All	0.905	0.990	.012	7	view →
CCRCC	DFS	Median	III,IV	0.600	0.831	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

UPRT–LUAD (OS)

Open the LUAD breakdown →