UPRT

Across TCGA patient cohorts, UPRT mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UPRT-associated genes across cancer lineages are FoxM1, ACC1, and JNK_pT183_Y185. Each is linked with UPRT in more than 1 cancer types. Because this analysis shows association rather than direction, both UPRT-to-partner and partner-to-UPRT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by UPRT-low versus UPRT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UPRT→partner) and Y-score (partner→UPRT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.190	+1.289	.021	.023	3	2
UCEC	ACC1 →	+0.274	+2.598	.018	.005	3	2
UCEC	JNK_pT183_Y185 →	-0.169	-2.087	.001	.005	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.316	-1.765	.028	.013	3	2
UCEC	Shc_pY317 →	-0.147	-1.777	.002	.002	3	2
UCEC	ASNS →	+0.567	+3.087	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

FoxM1 by UPRT expression — UCEC

Explore this box plot interactively →