UPRT

Across TCGA cell cohorts, UPRT RNA expression is significantly associated with the go_rna of many other GO terms, with 3,706 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UPRT-associated GO terms across cancer lineages are Regulation of hydrogen peroxide metabolic process, Macroautophagy, and Negative regulation of protein modification by small protein conjugation or removal. Each is linked with UPRT in more than 8 cancer types. Because this analysis shows association rather than direction, both UPRT-to-partner and partner-to-UPRT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of hydrogen peroxide metabolic process grouped by UPRT-low versus UPRT-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UPRT→partner) and Y-score (partner→UPRT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Regulation of hydrogen peroxide metabolic process →	+0.126	+0.670	.001	.001	3	9
SOFT_TISSUE	Macroautophagy →	+0.062	+0.684	<.001	<.001	3	9
LUNG_SCLC	Negative regulation of protein modification by small protein conjugation or removal →	+0.075	+1.014	<.001	.001	3	8
OVARY	Spindle elongation →	+0.182	+0.608	.005	.002	3	8
BLOOD_Leukemia	Cell division →	+0.061	+0.726	<.001	<.001	3	8
OVARY	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.099	+0.614	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,706 associations by consensus.

Regulation of hydrogen peroxide metabolic process by UPRT expression — CNS

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