UPRT

Across TCGA cell cohorts, UPRT mutation is significantly associated with the mutation status of many other genes, with 1,030 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UPRT-associated genes across cancer lineages are TAF5L, CUL7, and TAF2. Each is linked with UPRT in more than 2 cancer types. Because this analysis shows association rather than direction, both UPRT-to-partner and partner-to-UPRT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAF5L grouped by UPRT-low versus UPRT-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UPRT→partner) and Y-score (partner→UPRT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TAF5L →	+5.297	+5.297	.004	.004	1	3
BLOOD_Lymphoma	CUL7 →	+4.429	+5.247	.005	.005	1	2
BREAST	TAF2 →	+5.297	+5.297	.004	.004	1	2
BREAST	SNAP91 →	+4.297	+4.857	.009	.009	1	2
BREAST	SREBF1 →	+5.297	+5.297	.004	.004	1	2
BREAST	NFATC2 →	+4.297	+4.857	.009	.009	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,030 associations by consensus.

TAF5L by UPRT expression — BREAST

Explore this box plot interactively →