UPP2

Across TCGA patient cohorts, UPP2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UPP2-associated genes across cancer lineages are 4E-BP1, ERK2, and JNK2. Each is linked with UPP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UPP2-to-partner and partner-to-UPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by UPP2-low versus UPP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UPP2→partner) and Y-score (partner→UPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.381	+2.351	.001	.018	3	2
UCEC	ERK2 →	+0.173	+2.000	.046	.032	3	1
UCEC	JNK2 →	+0.269	+3.196	.002	.009	3	1
UCEC	Rab11 →	-0.152	-2.000	.020	.032	3	1
UCEC	Shc_pY317 →	-0.166	-2.700	.015	.006	3	1
UCEC	YB-1 →	+0.155	+2.999	.030	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

4E-BP1 by UPP2 expression — UCEC

Explore this box plot interactively →