UPP2

Across TCGA cell cohorts, UPP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 773 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible UPP2-associated GO terms across cancer lineages are Negative regulation of autophagy, Macroautophagy, and Vesicle budding from membrane. Each is linked with UPP2 in more than 6 cancer types. Because this analysis shows association rather than direction, both UPP2-to-partner and partner-to-UPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of autophagy grouped by UPP2-low versus UPP2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UPP2→partner) and Y-score (partner→UPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of autophagy →	+0.056	+0.038	.003	.005	3	7
BLOOD_Lymphoma	Macroautophagy →	+0.032	+0.011	.001	.002	3	6
PANCREAS	Vesicle budding from membrane →	+0.058	+0.028	<.001	.002	3	5
BLOOD_Lymphoma	Process utilizing autophagic mechanism →	+0.034	+0.011	<.001	.002	3	5
BLOOD_Lymphoma	Autophagy →	+0.034	+0.011	<.001	.002	3	5
BONE	Response to rapamycin →	+0.064	+0.028	.006	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 773 associations by consensus.

Negative regulation of autophagy by UPP2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →