UPP2

Across TCGA cell cohorts, UPP2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible UPP2-associated genes across cancer lineages are OR12D2, CD300H, and ADGRA1. Each is linked with UPP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UPP2-to-partner and partner-to-UPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR12D2 grouped by UPP2-low versus UPP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UPP2→partner) and Y-score (partner→UPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR12D2 →	+0.079	+4.467	<.001	.004	3	1
LARGE_INTESTINE	CD300H →	+0.033	+4.415	<.001	.007	3	1
BLOOD_Leukemia	ADGRA1 →	+0.006	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.046	+5.969	<.001	.001	3	1
STOMACH	DPPA5 →	+1.309	+4.285	.001	.007	3	1
STOMACH	KRT25 →	+0.005	+4.285	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR12D2 by UPP2 expression — LARGE_INTESTINE

Explore this box plot interactively →