UPK3BL1

Across TCGA cell cohorts, UPK3BL1 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UPK3BL1-associated genes across cancer lineages are TBC1D21, CCR8, and LYPD2. Each is linked with UPK3BL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UPK3BL1-to-partner and partner-to-UPK3BL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D21 grouped by UPK3BL1-low versus UPK3BL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UPK3BL1→partner) and Y-score (partner→UPK3BL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	2
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
SOFT_TISSUE	LYPD2 →	+0.052	+5.369	.006	.004	3	1
LUNG_NSCLC_LUSC	LRRC53 →	+0.007	+4.108	<.001	.005	3	1
BREAST	SYCN →	+0.057	+5.169	<.001	.005	3	1
BREAST	C3orf56 →	+0.006	+5.781	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

TBC1D21 by UPK3BL1 expression — LARGE_INTESTINE

Explore this box plot interactively →