UPK3B

Across TCGA pan-cancer cohorts, UPK3B RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of UPK3B’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where UPK3B RNA is repressed in tumor relative to normal tissue. In most cancer types UPK3B is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and KICH are the cancer types where UPK3B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UPK3B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	−5.998	<.001	11	view →
LUSC	Female	II,III,IV	−5.261	<.001	9	view →
KICH	All	All	−0.584	<.001	5	view →
KIRP	All	II,III,IV	+0.580	.009	3	view →
LIHC	Female	All	+0.500	.001	3	view →
KIRC	Male	All	+0.267	.009	3	view →
BLCA	All	IV	+3.740	.031	2	view →
PRAD	All	All	−0.552	<.001	2	view →
READ	Male	All	−0.240	.019	2	view →
CHOL	All	All	+1.426	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

UPK3B–LUAD

Open the LUAD breakdown →