UPK1A

Across TCGA pan-cancer cohorts, UPK1A Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated UPK1A data layer compared with 18 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher UPK1A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated UPK1A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD, LUAD, and UCEC are the cancer types where UPK1A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.140	0.871	<.001	27	view →
LUAD	OS	Median	II,III,IV	0.090	0.709	<.001	23	view →
UCEC	DFS	Median	II,III,IV	1.000	0.444	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

UPK1A–COAD (OS)

Open the COAD breakdown →