UPK1A

Across TCGA pan-cancer cohorts, UPK1A mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated UPK1A data layer compared with 18 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher UPK1A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated UPK1A expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, GBM, and CCRCC are the cancer types where UPK1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	1.000	0.385	.017	16	view →
GBM	DFS	Tertile	All	0.694	0.906	.007	13	view →
CCRCC	OS	Median	All	1.000	0.922	.030	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

UPK1A–PDAC (OS)

Open the PDAC breakdown →