UPK1A

Across TCGA patient cohorts, UPK1A mutation is significantly associated with the RNA expression of many other genes, with 1,914 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UPK1A-associated genes across cancer lineages are GLTP, LIN7C, and SLC25A4. Each is linked with UPK1A in more than 2 cancer types. Because this analysis shows association rather than direction, both UPK1A-to-partner and partner-to-UPK1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GLTP grouped by UPK1A-low versus UPK1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UPK1A→partner) and Y-score (partner→UPK1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GLTP →	+0.404	+4.000	.004	<.001	3	3
UCEC	LIN7C →	+0.526	+2.815	.004	.001	3	2
UCEC	SLC25A4 →	+0.490	+2.098	.003	.003	3	2
UCEC	HAUS1 →	+0.575	+3.480	.001	.002	3	2
UCEC	PAFAH2 →	+0.509	+2.595	<.001	<.001	3	2
UCEC	HSPA4L →	+0.834	+2.823	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,914 associations by consensus.

GLTP by UPK1A expression — UCEC

Explore this box plot interactively →