UPK1A

Across TCGA patient cohorts, UPK1A mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UPK1A-associated genes across cancer lineages are EGFR_pY1068, Rad50, and 4E-BP1. Each is linked with UPK1A in more than 1 cancer types. Because this analysis shows association rather than direction, both UPK1A-to-partner and partner-to-UPK1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by UPK1A-low versus UPK1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UPK1A→partner) and Y-score (partner→UPK1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.269	-1.807	.009	.027	3	2
UCEC	Rad50 →	-0.220	-1.807	.027	.027	3	2
UCEC	4E-BP1 →	+0.374	+3.489	<.001	.002	3	2
UCEC	FoxM1 →	+0.306	+2.321	.004	.006	3	1
UCEC	INPP4B →	-0.361	-3.584	.006	.002	2	2
UCEC	JNK2 →	+0.171	+1.807	.036	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

EGFR_pY1068 by UPK1A expression — UCEC

Explore this box plot interactively →