UPK1A

Across TCGA cell cohorts, UPK1A mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UPK1A-associated genes across cancer lineages are CCDC172, TEX48, and PRM1. Each is linked with UPK1A in more than 1 cancer types. Because this analysis shows association rather than direction, both UPK1A-to-partner and partner-to-UPK1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC172 grouped by UPK1A-low versus UPK1A-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UPK1A→partner) and Y-score (partner→UPK1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CCDC172 →	+0.023	+4.108	.004	.005	3	1
BLOOD_Leukemia	TEX48 →	+0.039	+5.060	<.001	.001	3	1
LARGE_INTESTINE	PRM1 →	+0.518	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR13C7 →	+0.016	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CCDC172 by UPK1A expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →