UPF3B

Across TCGA pan-cancer cohorts, UPF3B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UPF3B data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher UPF3B mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated UPF3B expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where UPF3B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.929	0.682	.004	46	view →
HNSC	DFS	Tertile	All	0.215	0.810	.010	10	view →
LUAD	OS	Median	All	0.676	1.000	.005	4	view →
CCRCC	DFS	Tertile	II,III,IV	0.720	0.395	.024	2	view →
LSCC	OS	Tertile	All	1.000	0.922	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UPF3B–PDAC (OS)

Open the PDAC breakdown →