UPF3B

Across TCGA patient cohorts, UPF3B mutation is significantly associated with the RNA expression of many other genes, with 1,556 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UPF3B-associated genes across cancer lineages are C1QC, HK3, and AAGAB. Each is linked with UPF3B in more than 1 cancer types. Because this analysis shows association rather than direction, both UPF3B-to-partner and partner-to-UPF3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QC grouped by UPF3B-low versus UPF3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UPF3B→partner) and Y-score (partner→UPF3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C1QC →	+0.712	+2.247	.001	.001	3	2
UCEC	HK3 →	+0.563	+1.958	<.001	.002	3	2
UCEC	AAGAB →	+0.323	+1.537	.002	.001	3	2
UCEC	MIER2 →	+0.237	+1.494	.005	.001	3	2
UCEC	PSMC3IP →	+0.470	+1.724	<.001	.001	3	2
BRCA	RN7SKP213 →	+0.151	+3.875	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,556 associations by consensus.

C1QC by UPF3B expression — UCEC

Explore this box plot interactively →