UPF3AP3

Across TCGA pan-cancer cohorts, UPF3AP3 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of UPF3AP3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where UPF3AP3 RNA is repressed in tumor relative to normal tissue. In most cancer types UPF3AP3 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where UPF3AP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UPF3AP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	−0.294	<.001	11	view →
HNSC	Male	II,III,IV	+0.379	<.001	8	view →
THCA	All	II,III,IV	−0.302	.004	6	view →
STAD	Male	All	+0.716	<.001	5	view →
LIHC	Female	All	+0.256	<.001	5	view →
BLCA	All	III,IV	+0.482	.005	4	view →
COAD	All	All	+0.319	.002	4	view →
CHOL	All	All	+0.728	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

UPF3AP3–KIRC

Open the KIRC breakdown →