UPF3A

Across TCGA pan-cancer cohorts, UPF3A Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated UPF3A data layer compared with 27 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher UPF3A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated UPF3A expression acts as an unfavorable survival marker.

BLCA, UCEC, and COAD are the cancer types where UPF3A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	III,IV	0.117	0.684	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
COAD	OS	Median	All	0.176	0.673	.038	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

UPF3A–BLCA (OS)

Open the BLCA breakdown →