UPF3A

Across TCGA pan-cancer cohorts, UPF3A mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated UPF3A data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher UPF3A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated UPF3A expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, UCEC, and CCRCC are the cancer types where UPF3A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	IV	0.934	0.272	.017	6	view →
UCEC	DFS	Tertile	III,IV	0.529	1.000	.049	4	view →
CCRCC	DFS	Quartile	All	1.000	0.715	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

UPF3A–PDAC (DFS)

Open the PDAC breakdown →