UPF1

Across TCGA pan-cancer cohorts, UPF1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UPF1 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher UPF1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UPF1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where UPF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.623	0.807	.009	11	view →
LUAD	DFS	Tertile	II,III,IV	0.961	0.741	.012	8	view →
PDAC	DFS	Median	III,IV	0.426	0.835	.035	2	view →
CCRCC	DFS	Median	III,IV	0.774	0.207	.047	2	view →
LSCC	OS	Tertile	III,IV	0.790	1.000	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UPF1–HNSC (OS)

Open the HNSC breakdown →