UPF1

Across TCGA patient cohorts, UPF1 mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UPF1-associated genes across cancer lineages are Bcl-xL, Cyclin-E1, and TFRC. Each is linked with UPF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both UPF1-to-partner and partner-to-UPF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bcl-xL grouped by UPF1-low versus UPF1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UPF1→partner) and Y-score (partner→UPF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Bcl-xL →	+0.217	+2.820	.026	.035	3	3
BLCA	Cyclin-E1 →	+0.460	+2.999	.009	.035	3	3
UCEC	TFRC →	+0.518	+4.087	.001	<.001	3	3
UCEC	Cyclin-E2 →	+0.181	+2.009	<.001	<.001	3	3
CESC	C-Raf →	+0.205	+3.169	.001	.017	3	2
UCEC	eIF4E →	+0.191	+2.013	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

Bcl-xL by UPF1 expression — BLCA

Explore this box plot interactively →