UPF1

Across TCGA cell cohorts, UPF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,432 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible UPF1-associated GO terms across cancer lineages are Regulation of cell fate commitment, Negative regulation of protein localization to chromatin, and Regulation of anaphase-promoting complex-dependent catabolic process. Each is linked with UPF1 in more than 16 cancer types. Because this analysis shows association rather than direction, both UPF1-to-partner and partner-to-UPF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell fate commitment grouped by UPF1-low versus UPF1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UPF1→partner) and Y-score (partner→UPF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of cell fate commitment →	+0.180	+1.215	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Negative regulation of protein localization to chromatin →	+0.193	+0.725	<.001	<.001	3	17
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.162	+0.732	<.001	<.001	3	17
BONE	Mitotic chromosome condensation →	+0.142	+0.561	<.001	.001	3	17
BONE	Transcription pausing by RNA polymerase II →	+0.191	+0.864	<.001	<.001	3	16
STOMACH	Regulation of cell fate specification →	+0.173	+1.115	<.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,432 associations by consensus.

Regulation of cell fate commitment by UPF1 expression — STOMACH

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