UPF1

Across TCGA cell cohorts, UPF1 mutation is significantly associated with the RNA expression of many other genes, with 1,419 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UPF1-associated genes across cancer lineages are NUTM1, FBXW10, and CLLU1-AS1. Each is linked with UPF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UPF1-to-partner and partner-to-UPF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUTM1 grouped by UPF1-low versus UPF1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UPF1→partner) and Y-score (partner→UPF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NUTM1 →	+0.017	+4.459	.001	.003	3	2
LARGE_INTESTINE	FBXW10 →	+0.174	+2.491	.001	.001	3	2
URINARY_TRACT	CLLU1-AS1 →	+0.113	+5.087	<.001	.004	3	1
URINARY_TRACT	FABP9 →	+0.056	+5.087	<.001	.004	3	1
URINARY_TRACT	CFAP97D2 →	+0.043	+5.087	<.001	.004	3	1
BLOOD_Leukemia	CPN1 →	+0.108	+3.820	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,419 associations by consensus.

NUTM1 by UPF1 expression — SKIN

Explore this box plot interactively →