UPB1

Across TCGA patient cohorts, UPB1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UPB1-associated genes across cancer lineages are eEF2, Src_pY527, and EGFR_pY1068. Each is linked with UPB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UPB1-to-partner and partner-to-UPB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by UPB1-low versus UPB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UPB1→partner) and Y-score (partner→UPB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.321	+1.678	.019	.023	3	2
UCEC	Src_pY527 →	-0.504	-3.459	.002	.005	3	2
UCEC	EGFR_pY1068 →	-0.270	-2.700	.005	.006	3	1
UCEC	A-Raf_pS299 →	-0.136	-3.584	.002	.002	3	1
UCEC	ERK2 →	+0.188	+2.584	.010	.001	3	1
UCEC	IGFBP2 →	-0.724	-3.459	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

eEF2 by UPB1 expression — UCEC

Explore this box plot interactively →