UPB1

Across TCGA cell cohorts, UPB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,748 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UPB1-associated GO terms across cancer lineages are Positive regulation of acetylcholine secretion, neurotransmission, Regulation of acetylcholine secretion, neurotransmission, and Positive regulation of circadian sleep/wake cycle, sleep. Each is linked with UPB1 in more than 10 cancer types. Because this analysis shows association rather than direction, both UPB1-to-partner and partner-to-UPB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of acetylcholine secretion, neurotransmission grouped by UPB1-low versus UPB1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UPB1→partner) and Y-score (partner→UPB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of acetylcholine secretion, neurotransmission →	+1.709	+0.950	<.001	.002	3	11
LIVER	Regulation of acetylcholine secretion, neurotransmission →	+1.213	+0.693	<.001	.007	3	10
BREAST	Positive regulation of circadian sleep/wake cycle, sleep →	+1.238	+0.456	<.001	.001	3	9
BLOOD_Leukemia	Regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway →	+0.099	+1.087	.001	<.001	3	5
SOFT_TISSUE	Regulation of glycogen biosynthetic process →	+0.060	+0.156	.003	.009	3	5
LUNG_NSCLC_LUAD	Positive regulation of synaptic transmission, cholinergic →	-0.148	-0.169	<.001	.004	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,748 associations by consensus.

Positive regulation of acetylcholine secretion, neurotransmission by UPB1 expression — LIVER

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