UPB1

Across TCGA cell cohorts, UPB1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UPB1-associated genes across cancer lineages are C5orf52, VSIG4, and KRTAP10-2. Each is linked with UPB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UPB1-to-partner and partner-to-UPB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C5orf52 grouped by UPB1-low versus UPB1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UPB1→partner) and Y-score (partner→UPB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	C5orf52 →	+0.138	+5.228	<.001	.005	3	1
LARGE_INTESTINE	VSIG4 →	+0.025	+2.791	<.001	.005	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.051	+4.479	<.001	<.001	3	1
LARGE_INTESTINE	ADORA3 →	+0.037	+3.584	.005	.006	3	1
BLOOD_Leukemia	OC90 →	+0.013	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

C5orf52 by UPB1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →