UNKL

Across TCGA pan-cancer cohorts, UNKL mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UNKL data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher UNKL mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated UNKL expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

LUAD, GBM, and HNSC are the cancer types where UNKL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.943	0.711	.002	34	view →
GBM	DFS	Tertile	All	0.468	0.299	.021	14	view →
HNSC	OS	Median	III,IV	0.935	0.796	.022	11	view →
CCRCC	OS	Median	III,IV	0.836	0.597	.022	7	view →
LSCC	DFS	Quartile	II,III,IV	0.836	1.000	.019	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UNKL–LUAD (OS)

Open the LUAD breakdown →