UNKL

Across TCGA patient cohorts, UNKL mutation is significantly associated with the RNA expression of many other genes, with 1,858 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNKL-associated genes across cancer lineages are RN7SKP36, RN7SKP65, and RPL35AP10. Each is linked with UNKL in more than 2 cancer types. Because this analysis shows association rather than direction, both UNKL-to-partner and partner-to-UNKL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP36 grouped by UNKL-low versus UNKL-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNKL→partner) and Y-score (partner→UNKL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SKP36 →	+0.674	+4.693	<.001	.007	3	3
COAD	RN7SKP65 →	+0.234	+5.251	<.001	.003	3	3
SARC	RPL35AP10 →	+0.163	+4.432	.008	.002	3	2
SARC	MIR6775 →	+0.578	+3.792	<.001	.007	3	2
COAD	RNU7-169P →	+0.998	+5.547	<.001	.002	3	2
COAD	DPPA2P1 →	+0.192	+4.790	.005	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,858 associations by consensus.

RN7SKP36 by UNKL expression — COAD

Explore this box plot interactively →