UNKL

Across TCGA patient cohorts, UNKL mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNKL-associated genes across cancer lineages are JNK2, MEK1, and Notch1. Each is linked with UNKL in more than 1 cancer types. Because this analysis shows association rather than direction, both UNKL-to-partner and partner-to-UNKL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by UNKL-low versus UNKL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNKL→partner) and Y-score (partner→UNKL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.249	+2.232	<.001	.005	3	1
UCEC	MEK1 →	+0.449	+2.736	<.001	<.001	3	1
UCEC	Notch1 →	+0.125	+2.817	.015	.001	3	1
UCEC	p62 Lck ligand →	+0.381	+2.424	.001	.001	3	1
UCEC	PDCD4 →	-0.484	-1.847	.005	.008	3	1
UCEC	Rad50 →	-0.259	-2.736	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

JNK2 by UNKL expression — UCEC

Explore this box plot interactively →