UNKL

Across TCGA cell cohorts, UNKL RNA expression is significantly associated with the go_rna of many other GO terms, with 3,888 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UNKL-associated GO terms across cancer lineages are Calcium-independent cell-matrix adhesion, CAMP/PKA signal transduction, and Regulation of pattern recognition receptor signaling pathway. Each is linked with UNKL in more than 13 cancer types. Because this analysis shows association rather than direction, both UNKL-to-partner and partner-to-UNKL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Calcium-independent cell-matrix adhesion grouped by UNKL-low versus UNKL-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UNKL→partner) and Y-score (partner→UNKL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Calcium-independent cell-matrix adhesion →	+0.226	+1.571	<.001	<.001	3	14
BONE	CAMP/PKA signal transduction →	+0.224	+1.330	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of pattern recognition receptor signaling pathway →	+0.071	+1.508	.001	<.001	3	14
BLOOD_Lymphoma	Multi-pass transmembrane protein insertion into ER membrane →	+0.173	+1.103	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.185	+1.613	<.001	<.001	3	13
PANCREAS	Metanephric proximal tubule development →	+0.232	+1.050	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,888 associations by consensus.

Calcium-independent cell-matrix adhesion by UNKL expression — BONE

Explore this box plot interactively →