UNKL

Across TCGA cell cohorts, UNKL mutation is significantly associated with the RNA expression of many other genes, with 254 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UNKL-associated genes across cancer lineages are OR13D1, CCT8L2, and CDR1. Each is linked with UNKL in more than 1 cancer types. Because this analysis shows association rather than direction, both UNKL-to-partner and partner-to-UNKL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13D1 grouped by UNKL-low versus UNKL-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNKL→partner) and Y-score (partner→UNKL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR13D1 →	+0.025	+4.977	<.001	.002	3	2
PANCREAS	CCT8L2 →	+0.136	+5.614	<.001	.002	3	2
LUNG_NSCLC_LUSC	CDR1 →	+0.159	+4.108	.001	.005	3	2
LARGE_INTESTINE	PRDM7 →	+0.156	+2.472	<.001	.008	3	2
LARGE_INTESTINE	MMACHC →	+0.907	+3.364	<.001	.002	3	2
LARGE_INTESTINE	ENOPH1 →	+0.485	+3.364	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 254 associations by consensus.

OR13D1 by UNKL expression — SOFT_TISSUE

Explore this box plot interactively →