UNK

Across TCGA pan-cancer cohorts, UNK mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated UNK data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher UNK mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated UNK expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where UNK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	All	0.961	0.794	.031	5	view →
CCRCC	DFS	Median	All	0.742	0.866	.044	2	view →
PDAC	OS	Median	II,III,IV	0.940	0.723	.019	2	view →
LUAD	DFS	Quartile	All	1.000	0.666	.021	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

UNK–LSCC (OS)

Open the LSCC breakdown →