UNK

Across TCGA patient cohorts, UNK mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNK-associated genes across cancer lineages are p62 Lck ligand, EGFR_pY1173, and MSH6. Each is linked with UNK in more than 2 cancer types. Because this analysis shows association rather than direction, both UNK-to-partner and partner-to-UNK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by UNK-low versus UNK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNK→partner) and Y-score (partner→UNK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.364	+3.710	.006	<.001	3	3
COAD	EGFR_pY1173 →	+0.143	+2.849	.006	.034	3	3
UCEC	MSH6 →	-0.515	-1.874	<.001	.049	3	2
SKCM	p70-S6K →	+0.330	+3.169	.010	.019	2	2
SKCM	4E-BP1_pS65 →	+0.355	+2.820	<.001	.035	3	1
COAD	4E-BP1 →	+0.365	+2.815	.002	.036	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

p62 Lck ligand by UNK expression — UCEC

Explore this box plot interactively →