UNK

Across TCGA cell cohorts, UNK RNA expression is significantly associated with the go_rna of many other GO terms, with 5,094 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible UNK-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, DNA replication-dependent chromatin assembly, and Heterochromatin formation. Each is linked with UNK in more than 17 cancer types. Because this analysis shows association rather than direction, both UNK-to-partner and partner-to-UNK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by UNK-low versus UNK-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UNK→partner) and Y-score (partner→UNK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Epigenetic regulation of gene expression →	+0.076	+0.858	.001	.001	3	18
BONE	DNA replication-dependent chromatin assembly →	+0.145	+0.800	.005	.004	3	16
STOMACH	Heterochromatin formation →	+0.081	+0.808	.001	.001	3	16
PANCREAS	Constitutive heterochromatin formation →	+0.107	+0.829	.001	.002	2	15
PANCREAS	Microtubule organizing center organization →	+0.060	+0.604	.001	.008	3	14
BONE	Protein polymerization →	+0.078	+0.816	<.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,094 associations by consensus.

Epigenetic regulation of gene expression by UNK expression — STOMACH

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