UNK

Across TCGA cell cohorts, UNK mutation is significantly associated with the RNA expression of many other genes, with 425 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UNK-associated genes across cancer lineages are OR10K2, OR10T2, and ASZ1. Each is linked with UNK in more than 1 cancer types. Because this analysis shows association rather than direction, both UNK-to-partner and partner-to-UNK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10K2 grouped by UNK-low versus UNK-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNK→partner) and Y-score (partner→UNK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR10K2 →	+0.038	+4.196	<.001	.006	3	2
BLOOD_Leukemia	OR10T2 →	+0.634	+4.013	<.001	<.001	3	2
BLOOD_Leukemia	ASZ1 →	+0.080	+2.982	.005	.007	3	2
BLOOD_Leukemia	FOXD3 →	+0.422	+4.009	.001	.002	3	2
UPPER_AERODIGESTIVE_TRACT	IZUMO1R →	+0.053	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	FABP9 →	+0.060	+5.357	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 425 associations by consensus.

OR10K2 by UNK expression — BREAST

Explore this box plot interactively →