UNC93B7

Across TCGA patient cohorts, UNC93B7 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,720 significant associations in total. THYM shows the largest number of these associations.

The most reproducible UNC93B7-associated GO terms across cancer lineages are Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage, Lysosomal lumen acidification, and Regulation of type I interferon-mediated signaling pathway. Each is linked with UNC93B7 in more than 10 cancer types. Because this analysis shows association rather than direction, both UNC93B7-to-partner and partner-to-UNC93B7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage grouped by UNC93B7-low versus UNC93B7-high in THYM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC93B7→partner) and Y-score (partner→UNC93B7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage →	+0.054	+1.023	<.001	<.001	3	11
THYM	Lysosomal lumen acidification →	+0.023	+0.931	<.001	<.001	3	8
STAD	Regulation of type I interferon-mediated signaling pathway →	+0.051	+0.129	<.001	<.001	3	8
ESCA	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.075	+0.143	<.001	<.001	3	7
ESCA	L-leucine catabolic process →	+0.048	+0.191	<.001	<.001	3	7
ESCA	Riboflavin metabolic process →	+0.085	+0.122	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,720 associations by consensus.

Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by UNC93B7 expression — THYM

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