UNC93B6

Across TCGA pan-cancer cohorts, UNC93B6 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated UNC93B6 data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher UNC93B6 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated UNC93B6 expression acts as an unfavorable survival marker, although some lineages such as CESC and SKCM show a favorable association.

CESC, SKCM, and BLCA are the cancer types where UNC93B6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	III,IV	0.692	0.224	.003	56	view →
SKCM	OS	Tertile	All	0.931	0.840	<.001	49	view →
BLCA	OS	Median	All	0.691	0.548	.003	49	view →
ACC	OS	Tertile	All	0.252	0.783	.002	29	view →
LAML	DFS	Tertile	All	0.301	0.634	.001	28	view →
LGG	OS	Quartile	All	0.670	0.846	.002	19	view →
STAD	DFS	Median	IV	0.183	0.575	.015	12	view →
CHOL	OS	Median	IV	0.208	0.948	.010	12	view →
MESO	DFS	Median	III,IV	0.630	0.266	.015	12	view →
THYM	DFS	Quartile	II,III,IV	0.945	0.625	.027	8	view →
KICH	OS	Tertile	II,III,IV	0.653	0.920	.025	8	view →
UCEC	OS	Quartile	IV	0.847	0.326	.034	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

UNC93B6–CESC (DFS)

Open the CESC breakdown →