UNC93B3

Across TCGA pan-cancer cohorts, UNC93B3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated UNC93B3 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher UNC93B3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated UNC93B3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UVM show a favorable association.

HNSC, UVM, and KIRP are the cancer types where UNC93B3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.465	0.250	<.001	97	view →
UVM	OS	Median	All	0.773	0.438	<.001	85	view →
KIRP	DFS	Quartile	All	1.000	0.505	.001	40	view →
BLCA	OS	Tertile	All	0.701	0.498	.001	38	view →
LUAD	DFS	Quartile	All	0.619	0.751	.007	31	view →
PCPG	DFS	Median	All	0.809	0.952	.003	28	view →
DLBC	OS	Median	IV	0.362	1.000	.003	28	view →
SKCM	OS	Quartile	III,IV	0.636	0.350	.007	25	view →
READ	DFS	Quartile	All	0.575	0.919	.002	18	view →
UCEC	DFS	Tertile	III,IV	0.887	0.758	.018	16	view →
BRCA	OS	Tertile	IV	0.309	1.000	.014	16	view →
LIHC	DFS	Quartile	II,III,IV	0.441	0.225	.010	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

UNC93B3–HNSC (OS)

Open the HNSC breakdown →