UNC80

Across TCGA pan-cancer cohorts, UNC80 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated UNC80 data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher UNC80 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated UNC80 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ACC, UCEC, and DLBC are the cancer types where UNC80 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.010	0.667	<.001	45	view →
UCEC	DFS	Median	All	0.948	0.821	.005	32	view →
DLBC	DFS	Median	II,III,IV	0.065	0.829	<.001	21	view →
CHOL	OS	Median	All	0.133	0.743	<.001	18	view →
OV	OS	Median	IV	0.028	0.759	.002	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
KICH	DFS	Median	All	0.121	0.867	.023	5	view →
ESCA	DFS	Median	All	0.322	0.543	.045	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

UNC80–ACC (DFS)

Open the ACC breakdown →